Publications


  1. Block copolymer concepts of how transcription organizes the stem cell genome
    Bao, Y.; Ma, S.; Shen, X.; Hilbert, L.
    2026. Current Opinion in Genetics and Development, 96, 102428. doi:10.1016/j.gde.2025.102428
  2. Chromatin unfolding via loops can drive clustered transposon insertion
    Prizak, R.; Gadzekpo, A.; Hilbert, L.
    2025. Biophysical Journal, 124 (22), 3908–3922. doi:10.1016/j.bpj.2025.03.038
  3. Chromatin‐associated condensates as an inspiration for the system architecture of future DNA computers
    Hilbert, L.; Gadzekpo, A.; Vecchio, S. L.; Wellhäusser, M.; Tschurikow, X.; Prizak, R.; Becker, B.; Burghart, S.; Oprzeska-Zingrebe, E. A.
    2025. Annals of the New York Academy of Sciences, 1552 (1), 12–28. doi:10.1111/nyas.15415
  4. Investigating the transcriptional regulation of midkine a during adult neurogenesis in zebrafish. PhD dissertation
    Chen, J.
    2025, March 13. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000179272
  5. Personalized Drug Response Profiling for Patient-Derived CLL cells via Miniaturized Gene Expression and Drug Sensitivity Testing on Droplet Microarray. PhD dissertation
    El Khaled El Faraj, R.
    2025, February 19. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000178982
  6. Integrative Approaches for DNA Sequence‐Controlled Functional Materials
    Gadzekpo, A.; Oprzeska-Zingrebe, E. A.; Kozlowska, M.; Hilbert, L.; Stoev, I. D.
    2025. Advanced Functional Materials, Art.-Nr.: e19573. doi:10.1002/adfm.202519573
  7. Imaging Nuclear Clusters in Live Zebrafish Embryos
    Dongre, S.; Hilbert, L.; Vastenhouw, N. L.
    2025. Zygotic Genome Activation – Methods and Protocols. Ed.: M.C. Good, 89 – 117, Springer US. doi:10.1007/978-1-0716-4522-2_7
  8. Investigation of the molecular mechanisms of the neuronal differentiation in p2 domain in the spinal cord. PhD dissertation
    Cucun, G.
    2024, August 28. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000173043
  9. Exploring zebrafish spinal cord development and tissue regeneration through transcriptomic data analysis. PhD dissertation
    Chen, F.
    2024, August 27. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000173042
  10. Nanoliter Droplet Microarrays Combined with Impedance Spectroscopy and Sandwiching Method for Advancements in Miniaturized Cell Culture and Screening. PhD dissertation
    Zhou, M.
    2024, August 19. Karlsruher Institut für Technologie (KIT). doi:10.5445/IR/1000172875
  11. Discovery of Hidden Dynamic Processes through AI-based Automated Active Learning: A Use Case in Light Microscopy
    Friederich, N.; Yamachui Sitcheu, A. J.; Neumann, O.; Mikut, R.; Hilbert, L.
    2024, March 12. AI and biology (2024), Heidelberg, Germany, March 12–15, 2024
  12. Der Zellkern als Vorbild für zukünftige DNA-Computerchips?
    Hilbert, L.
    2024. BIOspektrum, 30 (1), 19–22. doi:10.1007/s12268-024-2090-4
  13. Photon-Efficient Aberration Correction for 3D-STED Imaging of Thick Biological Specimens Using Sensorless Adaptive Optics
    Dai, S.; Kobitski, A.; Barati Sedeh, A.; Eroğlu-Kayıkçı, S.; Hilbert, L.; Nienhaus, G. U.
    2024. ACS Photonics, 11 (1), 310–320. doi:10.1021/acsphotonics.3c01558
  14. Stimulated emission double depletion nanoscopy with background correction at the single-pixel level
    Sedeh, A. B.; Kobitski, A.; Dai, S.; Eroğlu-Kayıkçı, S.; Nienhaus, K.; Hilbert, L.; Nienhaus, G. U.
    2023. Optics Letters, 48 (21), 5791–5794. doi:10.1364/OL.502001
  15. AI-based automated active learning for discovery of hidden dynamic processes: A use case in light microscopy
    Friederich, N.; Yamachui Sitcheu, A. J.; Neumann, O.; Eroglu-Kayıkçı, S.; Prizak, R.; Hilbert, L.; Mikut, R.
    2023. Proceedings-33. Workshop Computational Intelligence: Berlin, 23.-24. November 2023, 31–51, KIT Scientific Publishing. doi:10.48550/arXiv.2310.04461
  16. Amphiphiles Formed from Synthetic DNA-Nanomotifs Mimic the Stepwise Dispersal of Transcriptional Clusters in the Cell Nucleus
    Tschurikow, X.; Gadzekpo, A.; Tran, M. P.; Chatterjee, R.; Sobucki, M.; Zaburdaev, V.; Göpfrich, K.; Hilbert, L.
    2023. Nano Letters, 23 (17), 7815–7824. doi:10.1021/acs.nanolett.3c01301
  17. A DNA Segregation Module for Synthetic Cells
    Tran, M. P.; Chatterjee, R.; Dreher, Y.; Fichtler, J.; Jahnke, K.; Hilbert, L.; Zaburdaev, V.; Göpfrich, K.
    2023. Small, 19 (13), Art.-Nr.: 2202711. doi:10.1002/smll.202202711
  18. Synchronization of oscillatory growth prepares fungal hyphae for fusion
    Wernet, V.; Kriegler, M.; Kumpost, V.; Mikut, R.; Hilbert, L.; Fischer, R.
    2023. eLife, 12, Art.-Nr.: e83310. doi:10.7554/eLife.83310
  19. Noise facilitates entrainment of a population of uncoupled limit cycle oscillators
    Kumpost, V.; Hilbert, L.; Mikut, R.
    2023. Journal of The Royal Society Interface, 20 (198), Art.-Nr.: 20220781. doi:10.1098/rsif.2022.0781
  20. Deep-learning microscopy image reconstruction with quality control reveals second-scale rearrangements in RNA polymerase II clusters
    Hajiabadi, H.; Mamontova, I.; Prizak, R.; Pancholi, A.; Koziolek, A.; Hilbert, L.
    2022. (K. E. Nelson, Ed.) PNAS Nexus, 1 (3), 1–12. doi:10.1093/pnasnexus/pgac065
  21. RNA polymerase II clusters form in line with surface condensation on regulatory chromatin
    Hilbert, L.
    2022
  22. A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light
    Kumpošt, V.; Vallone, D.; Gondi, S. B.; Foulkes, N. S.; Mikut, R.; Hilbert, L.
    2021. Scientific reports, 11 (1), Art.-Nr.: 14497. doi:10.1038/s41598-021-93913-2
  23. Transcription organizes euchromatin via microphase separation
    Hilbert, L.; Sato, Y.; Kuznetsova, K.; Bianucci, T.; Kimura, H.; Jülicher, F.; Honigmann, A.; Zaburdaev, V.; Vastenhouw, N. L.
    2021. Nature Communications, 12 (1), Article no: 1360. doi:10.1038/s41467-021-21589-3
  24. RNA polymerase II clusters form in line with surface condensation on regulatory chromatin
    Pancholi, A.; Klingberg, T.; Zhang, W.; Prizak, R.; Mamontova, I.; Noa, A.; Sobucki, M.; Kobitski, A. Y.; Nienhaus, G. U.; Zaburdaev, V.; Hilbert, L.
    2021. Molecular Systems Biology, 17 (9), Art.Nr. e10272. doi:10.15252/msb.202110272
  25. The hierarchical packing of euchromatin domains can be described as multiplicative cascades
    Noa, A.; Kuan, H.-S.; Aschmann, V.; Zaburdaev, V.; Hilbert, L.
    2021. PLoS Computational Biology, 17 (5), e1008974. doi:10.1371/journal.pcbi.1008974
  26. Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis
    Sato, Y.; Hilbert, L.; Oda, H.; Wan, Y.; Heddleston, J. M.; Chew, T.-L.; Zaburdaev, V.; Keller, P.; Lionnet, T.; Vastenhouw, N.; Kimura, H.
    2019. Development <Cambridge>, 146 (19), Article: dev179127. doi:10.1242/dev.179127
  27. Super-resolution imaging of densely packed DNA in nuclei of zebrafish embryos using stimulated emission double depletion microscopy
    Zhang, W.; Noa, A.; Nienhaus, K.; Hilbert, L.; Nienhaus, G. U.
    2019. Journal of physics / D, 52 (41), Art. Nr.: 414001. doi:10.1088/1361-6463/ab3200
  28. Spreading of perturbations in myosin group kinetics along actin filaments
    Balassy, Z.; Lauzon, A.-M.; Hilbert, L.
    2019. Proceedings of the National Academy of Sciences of the United States of America, 116 (35), 17336–17344. doi:10.1073/pnas.1904164116