Welcome to the Institute of Biological and Chemical Systems – Functional Molecular Systems (IBCS-FMS)

IBCS-Functional Molecular Systems is an interdisciplinary institute combining fundamental research in Biology and Chemistry.
Our aim is to improve our understanding of biological processes (e.g. cellular communication or disease progression) using advanced materials and chemical processes.
We focus on developing new smart materials, miniaturized high content screening methods as well as design of novel biomedical tools for the treatment of diseases.


Building 319   


Specific Focuses of IBCS-FMS:

Biology:        Cell adhesion molecules, Wnt signaling 
Chemistry:    Combinatorial chemistry, surface chemistry, polymer chemistry

Technology Transfer at IBCS-FMS:

Several aspects of our research at IBCS-FMS have been transferred into Start-Ups:





Danielle SkropetaPrivate
Welcome Prof. Danielle Skropeta

We are happy to welcome Prof.  Danielle Skropeta from the University of Wollongong, Australia as a guest scientist in the group of Prof. Veronique Orian-Rousseau.
Prof. Skropeta has been awarded an International Excellence Fellowship from the KIT.

Congratulations to Privatdozent Gary Davidson

Gary successfully completed his Habilitation as a Privatdozent last Friday.

Siegfried WaldvogelE. Lichtenscheidt
New group leader

As of July 1, Professor Siegfried Waldvogel (JGU Mainz) is the new senior scientist and group leader at the IBCS-FMS in a part-time capacity.

FEBS Advanced Lecture CourseFEBS Advanced Lecture Course
Poster Award (1st Place)

Congratulations to Lisa-Marie Mehner (Orian-Rousseau Group) for receiving the poster  award for an outstanding poster presentation (1st Place) at the FEBS Advanced Lecture Course on Matrix Pathobiology in Crete, Greece.

Orian-Rousseau Lab: Check out our new paper in Cell Death & Disease!

Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop
Romina J. Walter, Steffen J. Sonnentag, Leonel Munoz-Sagredo, Melanie Merkel, Ludovic Richert, Felix Bunert, Yvonne M. Heneka, Thomas Loustau, Michael Hodder, Rachel A. Ridgway, Owen J. Sansom, Yves Mely, Ulrich Rothbauer, Mark Schmitt & Véronique Orian-Rousseau 

Link to paper
Support from the Chemical Industry Fund

Chemistry Fund supports Karlsruhe Institute of Technology - 5,000 euros for more digitalization in chemistry education.

Chemie.BW press release
Heterocycloalkynes Fused to a Heterocyclic Core: Searching for an Island with Optimal Stability-Reactivity Balance

New article by Stafan Bräse published at Journal of the American Chemical Society.

Link to article
POC_SHuaiKIT - AG Levkin
Substrate-Independent and Re-Writable Surface Patterning by Combining Polydopamine Coatings, Silanization, and Thiol-Ene Reaction

Levkin Group publishes a work on "Substrate-Independent and Re-Writable Surface Patterning by Combining Polydopamine Coatings, Silanization, and Thiol-Ene Reaction" in Advanced Functional Materials.
Congratulation to Shuai and all co-authors!

Link to publication
OrganogelsKIT - AG Levkin
Photodegradable organogels and their use to create organogel patterns and structures

Check out Levkin Group´s recent Advanced Functional Materials paper on photodegradable organogels and their use to create organogel patterns and structures, as well as their use as positive photoresists. Collaboration with Patrick Theato.
Congratulation to Johannes Scheiger and all co-authors!

Link to publication
Automatisierte chemische SynthesePatrick Hodapp, KIT
Automated chemical synthesis: reliable production and rapid knowledge gain

KIT Invests About Four Million Euros in Facility for Automated Synthesis - Efficient processes to accelerate the development of innovative materials

KIT press release
2 first prizes - NEULAND Innovation Contest 2021

- „LONGCOVIDMA: High-throughput testing of new efficient agents against LongCovid and Covid19 brain infections“ by Prof. Dr. Ute Schepers, Dr. Nicole Jung, Prof. Dr. Pavel Levkin, Prof. Dr. Stefan Bräse, Dr. Claudine Herlan, Dr. Anke Deckers and Dr. Anna Popova
- „Aquarray“ by Prof. Dr. Stefan Bräse and Prof. Dr. Pavel Levkin

Link to Homepage
Designing Inherently Photodegradable Cell-Adhesive Hydrogels for 3D Cell Culture

Check out recent publication of the Levkin Group in collaboration with Ute Schepers (IFG-CB) where they combined GelMA with PEG based gels to create photodegradable and biocompatible hydrogels for 3D cell culture.

Link to publication
Check out the new paper from the Orian-Rousseau group in "Blood"

CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues
Xiaobing Yu, Leonel Munoz-Sagredo, Karolin Streule, Patricia Muschong, Elisabeth Bayer, Romina Judith Walter, Julia Christine Gutjahr, Richard Greil, Miguel L Concha, Carsten Müller-Tidow, Tanja Nicole Hartmann, Véronique Orian-Rousseau

Link to paper
Latest Advanced Materials Paper

Introducing fully liquid "3D" structures that can contain organic liquids. Since there are no solid parts, it is self-healing, adaptive, and the liquid walls can release or extract components from the confined liquid.

Check out our paper “Liquid Wells as Self-Healing, Functional Analogues to Solid Vessels”:

Link to paper
319Anastasiya Sultanova , KIT
New research building at Campus North opened

Biology meets chemistry: Interdisciplinary research on 5 800 square meters. The new building was officially opened on October 29, 2020.