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AT A GLANCE

  • Organoids — patient-derived models
  • Mouse Genetics — conditional CD44 models
  • Phase I/Ib — clinical translation

 

OUR MISSION

Understanding how cancer spreads. Developing new therapies to stop it.
We investigate how tumour cells regain stem-cell properties, communicate with stromal and immune cells, and establish metastatic niches. Our goal is to expose vulnerabilities that can be therapeutically targeted.

 

 

RESEARCH THEMES​

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Cancer Plasticity

How differentiated tumour cells regain stem-cell properties after therapy.

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Metastatic Niche

How bone marrow-derived and stromal cells support pancreatic cancer spread.

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Contribution of Stromal Cells to Tumor Progression

How do cancer associated fibroblasts (CAFs), Pancreatic Stellate Cells (PSCs) and the extracellular matrix (ECM) regulate tumor progression.

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CD44 Signalling

How CD44 integrates MET, Wnt, TGFb and chemokine pathways.

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From Mechanism to Medicine

A CD44v6-derived peptide developed from our work has reached Phase I/Ib clinical evaluation.
Fundamental signalling biology translated into therapeutic strategies.

 

 

 

Our Approach

  1. Engineered Cancer Organoids
  2. Patient Samples/Patient-derived Organoids (PDOs)
  3. Conditional Mouse Models
  4. Therapeutic Validation

 

Join Our Lab

We welcome motivated Master's students, PhD candidates and postdoctoral researchers.
[ Open Positions ]